MNI SISCOM: An Open-Source Tool for Subtraction Ictal Single-photon emission CT Coregistered to MRI

Jeremy Moreau Presenter
Neurology and Neurosurgery
Montreal, Quebec 
Software Demonstrations 
Subtraction ictal single-photon emission CT coregistered to MRI (SISCOM) is a well-established technique for quantitative analysis of ictal (during a seizure) vs interictal (between seizures) SPECT images that can contribute to the identification of the epileptogenic zone in patients with drugā€resistant epilepsy (Ahnlide et al., 2007). However, there is presently a lack of user-friendly free and open-source software to compute SISCOM results from raw SPECT and MRI images. Multi-purpose image processing packages (Penny et al., 2011) already provide tools (e.g. coregistration and image calculators) that allow for the computation of SISCOM images, but obtaining these results typically requires several steps and necessitate a certain level of technical expertise. In this project, we developed an open-source graphical and command-line scriptable application to facilitate the process of computing SISCOM images. The goal of this project is to provide a freely available single-purpose and user-friendly tool to implement SISCOM.