Dynamically Acquired 1H MRS for Detection of 13C Labeled Cerebral Glucose Metabolism In-vivo

NMR spectroscopy has been used to probe metabolic pathways in vivo following infusion of specific 13C‐enriched substrates. In the current study, we investigate the ability of the short TE SPECIAL sequence and the MEGA-PRESS J-editing sequence, without a 13C radiofrequency channel, to detect 13C labeled glucose metabolism in the brain, and we demonstrate for the first time its application in human participants.