Simultaneous mapping of T2* and major neurotransmitters using MRSI at 3T

Fatimah Almomen Presenter
Purdue University
West Lafayette, IN 
United States
Oral Sessions 
Gamma-aminobutyric acid (GABA) and glutamate (Glu) are the brain's primary inhibitory (I) and excitatory (I) neurotransmitters. They are both strongly implicated in functional changes in neural circuitry and to be associated with learning and plasticity 1. The E-I balance/imbalance has been examined non-invasively by using proton (1H) magnetic resonance spectroscopy (MRS) to measure the glutamatergic-GABAergic system 2. MRS imaging (MRSI) methods are superior to single-voxel by recording multiple spectra from different regions simultaneously 3. In this study, we propose using a MEGA semi-LASER sequence with non-water suppressed metabolite-cycling as 2D MRSI data acquisition method at 3T for high-resolution GABA, Glutamate and T2*detection throughout a whole axial slice. Simultaneous measurement T2* with neurotransmitter maps will provide useful information on functional hemodynamic changes due physiological interventions.