Time-of-Flight-MRA-Derived-Probabilistic-Map of Each Major Cerebral Artery

The human brain is perfused by three main arteries: the middle cerebral arteries (MCA), anterior cerebral artery (ACA) and posterior cerebral arteries (PCA), each with distinct[1] and variable perfusion territories[2]. Attempts to parcellate the brain into functionally important regions have largely ignored these arteries; yet functional imaging methods are dependent on cerebral hemodynamics. Recent advancement in non-contrast enhanced Time-of-Flight (TOF) magnetic resonance angiography (MRA) allow non-invasive imaging of cerebral arteries and previous work from our lab has shown that this can be segmented into a whole-brain vascular tree[3], thus allowing for the isolation and study cerebral arteries with other MRI modalities. Here, we build on this by classifying tissue according to the cerebral artery's perfusion territory it resides in.